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What is dexamethasone? Dexamethasone is a corticosteroid that suppresses the release of inflammatory chemicals in the body. The drug is used to treat a variety of inflammatory conditions, including allergies and skin problems. This drug is also used to treat arthritis, lupus, ulcerative colitis, and breathing disorders. Warnings If you have a fungal infection anywhere on your body, you should not use dexamethasone . Tell your doctor about any medical conditions you have and any medications you're taking. There are many additional illnesses that can be affected by steroid use, as well as many other medications that can interact with steroids. If you have a major illness, fever, or infection, or if you undergo surgery or a medical emergency, your dosage may need to be adjusted. Any such occurrence that impacts you during treatment should be reported to your doctor. This drug can weaken your immune system, making infection more likely or worsening an infection you already have ...